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Stem Cell Related Patent Number US5250732
| Title: | Ketamine analogues for treatment of thrombocytopenia | | Inventors: | Kogan, Timothy P.; Half Moon Bay, CA, USA
Somers, Todd C.; Montara, CA, USA | | Summary: | Described herein are dehydronorketamine derivatives and methods of their use in the treatment of thrombocytopenia. The invention relates to 5,6-Dehydronorketamine and derivatives retaining the ?a,?-unsaturated carbonyl which are shown to influence the replication, differentiation or maturation of blood cells such as platelet progenitor cells in a manner similar to that of Michael or Michael-type acceptors and adducts. Therapeutic applications of such compounds are directed toward the treatment of thrombocytopenia. | | Abstract: | | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US5250732 | | Application Number: | US1991000732365 | | Date Filed: | 18/07/1991 | | Date Published: | 05/10/1993 | | Assignee: | Genentech, Inc., South San Francisco, CA, USA |
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