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Stem Cell Related Patent Number US5610056
| Title: | Use of stem cell factor interleukin-6 and soluble interleukin-6 receptor to induce the development of hematopoietic stem cells | | Inventors: | Nakahata, Tatsutoshi; Tokyo, Japan | | Summary: | Described herein are methods for the ex vivo expansion of multipotent hematopoietic cells via a process of culturing the cells with a combination of cytokines such as interleukin-6 and soluble interleukin-6 receptor in the presence of stem cell factor. Claims of the invention include improved proliferation, differentiation and terminal maturation of erythroid cells from normal human hematopoietic stem cells in a culture medium comprised with this combination of cytokines and stem cell factor. Therapeutic applications are included. | | Abstract: | Stem cell factor in combination with interleukin-6 and soluble interleukin-6 receptor supports proliferation, differentiation and terminal maturation of erythroid cells from normal human hematopoietic stem cells. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US5610056 | | Application Number: | US1994000340559 | | Date Filed: | 16/11/1994 | | Date Published: | 11/03/1997 | | Assignee: | Amgen Inc., Thousand Oaks, CA, USA
Tosoh Corporation, Tokyo, Japan |
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