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| Title: | OP-3- induced morphongenesis |
| Inventors: | Oppermann, Hermann; Medway, MA, USA Ozkaynak, Engin; Milford, MA, USA Kuberasampath, Thangavel; Medway, MA, USA Rueger, David C.; Hopkinton, MA, USA Pang, Roy H. L.; Etna, NH, USA Cohen, Charles M.; Medway, MA, USA |
| Summary: | This invention introduces the morphogenically active protein MOP-3, methods and uses thereof. Described herein are nucleic acid and amino acid sequences for MOP-3, methods for its production and expression in a biologically active form, and methods for its utilization in the induction of tissue morphogenesis in a mammal. Claims of the invention include the induction of endochondral bone formation in an in vivo assay, an increase in the progenitor cell population, and the ability of MOP-3 to stimulate progenitor cells to differentiate and maintain their differentiated phenotype both in vivo and in vitro. Therapeutic applications are included for inducing tissue-specific growth in vivo for the replacement of diseased or damaged tissue. |
| Abstract: | |
| US Patent Website: | Click Here for Full Text of Patent |
| Title Number: | US5854071 |
| Application Number: | US1997000901200 |
| Date Filed: | 28/07/1997 |
| Date Published: | 29/12/1998 |
| Assignee: | Creative BioMolecules, Inc., Boston, MA, USA |