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Stem Cell Related Patent Number US5908784
| Title: | In vitro chondrogenic induction of human mesenchymal stem cells | | Inventors: | Johnstone, Brian; Shaker Heights, OH, USA
Yoo, Jung; Shaker Heights, OH, USA | | Summary: | This invention introduces a composition for the in vitro chondrogenesis of human mesenchymal precursor cells and the in vitro formation of human chondrocytes. Described herein is a composition of chemically defined components which support the in vitro chondrogenesis of mesenchymal progenitor cells and which is comprised of isolated human mesenchymal stem cells that have been condensed into close proximity as a packed cell pellet that is in contact with at least one chondroinductive agent. Methods, materials and therapeutic applications are provided. | | Abstract: | Disclosed are a composition of chemically defined components which support the in vitro chondrogenesis of mesenchymal progenitor cells, a method for in vitro chondrogenic induction of such progenitor cells and a method of forming human chondrocytes in vitro from such progenitor cells. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US5908784 | | Application Number: | US1996000749484 | | Date Filed: | 15/11/1996 | | Date Published: | 01/06/1999 | | Assignee: | Case Western Reserve University, Cleveland, OH, USA |
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