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Stem Cell Related Patent Number US5911988
| Title: | Method for treating asthma using SCF antibody | | Inventors: | Brownell, Elise; Lafayette, CA, USA | | Summary: | This invention describes a novel method for the treatment of asthma and eosinophilia. Provided are pharmaceutical compositions comprising anti-SCF antibodies for the reduction of eosinophilia in the lungs of mammals. Further disclosed are methods of treating asthma within a murine model, and a method for the inhibition of eosinophil infiltration to the lungs of mammals, via the inhibition of interactions between Stem Cell Factor (SCF) and SCF-receptor protein. Such interactions comprise contacting the lung tissue by intra-tracheal administration with either an antibody or antigen-binding fragment thereof, wherein the antibody, or corresponding antigen-binding fragment, binds specifically with SCF, such that the binding which is responsible for inhibiting the interaction between SCF- and SCF-receptor protein results in the successful inhibition of the antigen-stimulated eosinophil infiltration to the lung. | | Abstract: | This invention provides pharmaceutical compositions comprising anti-SCF antibodies for the reduction of eosinophila in the lungs of mammals. This invention also provides for methods of treating asthma and generating a murine model for asthma. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US5911988 | | Application Number: | US1997000912541 | | Date Filed: | 18/08/1997 | | Date Published: | 15/06/1999 | | Assignee: | Bayer Corporation, West Haven, CT, USA
Univ. of Michigan, Ann Arbor, MI, USA |
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