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Stem Cell Related Patent Number US6287537
| Title: | Radioimmunotherapy of lymphoma using anti-CD20 antibodies | | Inventors: | Kaminski, Mark S.; Ann Arbor, MI, USA
Butchko, Gregory M.; Lake Forest, IL, USA
Glenn, Stephan D.; Sunnyvale, CA, USA
Wahl, Richard L.; Ann Arbor, MI, USA | | Summary: | This invention introduces a radioimmunotherapeutic process for the treatment of B-cell lymphoma. The invention relates to methods of immunotherapy via the administration of a radiolabeled antibody and an unlabeled antibody that binds to the antigen on the surface of the cells of B-cell lymphoma. Further provided are methods by which a patient is provided with both the unlabeled antibodies and the antibodies labeled with a radioisotope. Claims of the invention include tumor responses which can be obtained in a radiometric dosage range that does not require hematopoietic stem cell replacement as an adjunct therapy. | | Abstract: | Methods for the treatment of lymphoma by adminstration of a B cell-specific antibody are described. The invention encompasses providing to a patient both unlabeled antibodies and antibodies labeled with a radioisotope. A principal advantage of the method is that tumor responses can be obtained in a radiometric dose range that does not require hematopoietic stem cell replacement as an adjunct therapy. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US6287537 | | Application Number: | US1998000087392 | | Date Filed: | 29/05/1998 | | Date Published: | 11/09/2001 | | Assignee: | The Regents of the University of Michigan, Ann Arbor, MI, USA
Coulter Pharmaceutical, Inc., South San Francisco, CA, USA |
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