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Stem Cell Related Patent Number US6337184
| Title: | Molecular marker for muscle stem cells | | Inventors: | Miller, Jeffrey B.; Cambridge, MA, USA | | Summary: | This invention introduces methods of identifying a muscle stem cell via the detection of Bcl-2 promoter activity within a sample containing myogenic cells. Central to the invention is Bcl-2 expression as a molecular marker for muscle stem cells, for which methods are provided herein for determining whether a test compound modulates muscle stem cell differentiation or proliferation. Further disclosed are methods for expressing an exogenous coding sequence in a muscle stem cell. | | Abstract: | In accordance with the invention, Bcl-2 expression is a molecular marker for muscle stem cells. Thus, the invention provides methods for identifying and isolating muscle stem cells. In addition, the invention provides methods for determining whether a test compound modulates muscle stem cell differentiation and/or proliferation. Finally, the invention provides methods for expressing an exogenous coding sequence in a muscle stem cell. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US6337184 | | Application Number: | US1998000053031 | | Date Filed: | 01/04/1998 | | Date Published: | 08/01/2002 | | Assignee: | None |
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