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| Title: | Stem cell growth factor-like polypeptides |
| Inventors: | Nishikawa, Mitsuo; Gunma, Japan Labat, Ivan; Mountain View, CA, USA Drmanac, Radoje T.; Palo Alto, CA, USA Tang, Y. Tom; San Jose, CA, USA Chao, Cheng-Chi; Cupertino, CA, USA Mize, Nancy; Mountain View, CA, USA Childs, John; Sunnyvale, CA, USA |
| Summary: | This invention describes novel isolated stem cell polynucleotides and growth factor-like polypeptides encoded by such polynucleotides, and mutants or variants thereof. The polynucleotides are described as comprising nucleic acid sequences isolated from cDNA libraries prepared from mouse bone marrow and human fetal liver spleen, ovary, adult brain, lung tumor, spinal cord, cervix, ovary, endothelial cells, umbilical cord, placental, lymphocyte, lung fibroblast, fetal brain, and testis. Further disclosed are vectors containing processes for producing novel human secreted stem cell growth factor-like polypeptides, and antibodies specific for such polypeptides. Therapeutic applications are included, such as in the treatment of leukemia, hemophilia, osteoporosis, osteoarthritis, graft-versus-host disease, cancers, Alzheimer's disease, and Huntington's disease. |
| Abstract: | The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human and mouse secreted stem cell growth factor-like polypeptide. These polynucleotides comprise nucleic acid sequences isolated from cDNA libraries prepared from mouse bone marrow and human fetal liver spleen, ovary, adult brain, lung tumor, spinal cord, cervix, ovary, endothelial cells, umbilical cord, placental, lymphocyte, lung fibroblast, fetal brain, and testis. Other aspects of the invention include vectors containing processes for producing novel human secreted stem cell growth factor-like polypeptides, and antibodies specific for such polypeptides. |
| US Patent Website: | Click Here for Full Text of Patent |
| Title Number: | US6673904 |
| Application Number: | US2001000912935 |
| Date Filed: | 24/07/2001 |
| Date Published: | 06/01/2004 |
| Assignee: | Kirin Beer Kabushiki Kaisha, Tokyo, Japan Hyseq, Inc., Sunnyvale, CA, USA |