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Stem Cell Related Patent Number US6734336
| Title: | Gene-targeted non-human mammal with human fad presenilin mutation and generational offspring | | Inventors: | Scott, Richard W.; West Chester, PA, USA
Reaume, Andrew G.; Waterford, CT, USA
Dorfman, Karen; Waterford, CT, USA | | Summary: | This invention describes a novel gene-targeted mouse heterozygous for human Familial Alzheimer's Disease (FAD) mutation, and the generational offspring thereof, comprising a human mutation of FAD presenilin-1 (PS-1), a human transgene for FAD Swedish APP695, and a humanized Abeta (A?42) mutation, such that the A?42 protein level is elevated relative to the A?42 protein level in a wild-type mouse. Also included are therapeutic applications of such a non-human mammal in identifying compounds for the treatment of Alzheimer's disease. | | Abstract: | The present invention provides a gene-targeted, non-human mammal having a gene encoding a mutant protein product of a mutated FAD presenilin-1 (PS-1) gene, a human FAD Swedish mutation, and a humanized A.beta. mutation, and generational offspring thereof and a gene-targeted, non-human mammal having a gene encoding a mutant protein product of a mutated FAD PS-1 gene and a human Swedish APP695 mutation, and generational offspring thereof, as well as methods of identifying compounds useful in treating Alzheimer's disease, and to methods of treating Alzheimer's disease. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US6734336 | | Application Number: | US2000000621897 | | Date Filed: | 20/07/2000 | | Date Published: | 11/05/2004 | | Assignee: | Cephalon, Inc., West Chester, PA, USA |
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