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Stem Cell Related Patent Number US7115418
| Title: | Methods of proliferating undifferentiated neural cells | | Inventors: | Weiss, Samuel; Alberta, Canada
Reynolds, Brent; Alberta, Canada
Hammang, Joseph P.; Barrington, RI, USA
Baetge, E. Edward; Barrington, RI, USA | | Summary: | Described herein are methods of proliferation and differentiation in a culture containing one or more undifferentiated neural cells comprised of multipotent neural stem cells. The invention relates to the culturing of cells in a culture medium containing a proliferation-inducing growth factor, wherein the undifferentiated neural cells are comprised of nestin+ and glial fibrillary acidic protein (GFAP)?-; neurofilament (NF)?-; neuron specific enolase (NSE)?-; and myelin basic protein (MBP)?-. Also disclosed are properties of the growth factor, as are techniques of culturing the undifferentiated neural cells in a culture medium containing at least one proliferation-inducing growth factor. The authors further describe methods for making cDNA libraries and methods of screening biological agents which affect the proliferation and differentiation survival phenotype or function of CNS cells. Therapeutic applications in the treatment of neural disorders are included. | | Abstract: | The invention discloses methods of proliferation and differentiation of multipotent neural stem cells. Also provided are methods of making cDNA libraries and methods of screening biological agents which affect proliferation differentiation survival phenotype or function of CNS cells. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US7115418 | | Application Number: | US2002000199918 | | Date Filed: | 19/07/2002 | | Date Published: | 03/10/2006 | | Assignee: | NeuroSpheres Holdings Ltd., Calgary, Canada |
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